Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical plans and you will pharmacology out-of curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the major part of the newest red color out-of turmeric, a keen Indian liven that is taken from the latest rhizome of your tropical bush Curcuma longa, and that belongs to the Zingiberaceae nearest and https://kissbrides.com/fi/malaysiancupid-arvostelu/ dearest. In this chapter, we talk about the pharmacological situations regarding curcumin and you will discuss the latest molecular basics of these situations. We up coming feedback the latest proven and you can prospective systematic uses away from curcumin. Curcumin is well known over the years as the a curative representative, but the device away from action is detail by detail. This new pharmacological ramifications of curcumin appear to be caused by good synergism regarding networking sites off poor biochemical relations which have numerous physical aim within the interrelated signaling paths. Such plans tend to be enzymes such as for example cyclooxygenase, lipoxygenase and you can proteins kinases, and you may transcription facts eg NF-?B, STAT and you may Nrf2. Modulation of those molecules has an effect on downstream affectors which make the latest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial issues out of curcumin. These types of effects had been looked at within the health-related examples out-of curcumin to possess serious pain and you may inflammatory sickness, cancer, Alzheimer condition, cardio sickness, and all forms of diabetes. The products have used adjustable doses out-of curcuminwith additional wavelengths and you will years, to the general end you to high dosage of curcumin during the level of grams are required to obtain therapeutic effects. Read more
Curcumin: Synthesis, Growing Character inside the Problems Administration and you can Health Effects
Guide Chapter Types of plant-derived pharmaceuticals having get to be the attention of carried on and you may great browse and you can creativity desire have, at this point, become quite scarce. After years, the final 2 decades were described as a 100-fold boost in exactly how many scientific articles had written a-year one to was out of benefits into the means to access curcumin within the biomedicine. Read more
Structure, synthesis and you may physical affairs of curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many prospective pharmacological effects that will has healing apps in many state claims, while the talked about in detail in the earlier chapter. Although not, the potential health-related effectiveness out of curcumin is restricted by its physicochemical qualities regarding terrible water solubility and you can imbalance, which cause lowest bioavailability. Prodrugs of curcumin offer a way to upgrade of your own biopharmaceutical and you can pharmacokinetic qualities, and may allow exploitation of pharmacological outcomes of curcumin. Inside section, i very first opinion the fresh physicochemical and you can pharmacokinetics of curcumin. We following describe the appearance of curcumin prodrugs that have enhanced liquids solubility and you may improved chemical substances balance that is certainly converted returning to 100 % free curcumin on bioactivation inside vivo. I emphasize latest success in this area, having a focus on the construction, synthesis and you can assessment from prodrugs considering promoieties together with proteins, efas, nucleic acids, dicarboxylic acids, and you will polymeric product such as for example hyaluronic acidic and you may polyethylene glycol. Which part gets the basis for optimization of the physicochemical and you may biopharmaceutical characteristics plus the physical things out-of curcumin prodrugs, into mission playing with of them curcumin types during the clinical applications. Read more